Publications

Clinical research

Animal model

  • Eszter Somogyi, Mariann Kremlitzka, Zsolt Csiszovszki, Levente Molnár, Orsolya Lőrincz, József Tóth, Leon de Waal, Sofie Pattijn, Wencke Reineking, Andreas Beineke and Enikő R. Tőke: T cell immunity ameliorates COVID-19 disease severity and provides post-exposure prophylaxis after peptidevaccination, in Syrian hamsters DOI 10.3389/fimmu.2023.1111629
  • Eszter Somogyi, Zsolt Csiszovszki, Levente Molnár, Orsolya Lőrincz, József Tóth, Sofie Pattijn, Jana Schockaert, Aurélie Mazy, István Miklós, Katalin Pántya, Péter Páles and Enikő R. Tőke: A peptide vaccine candidate tailored to individuals’ genetics mimics the multi-targeted T cell immunity of COVID-19 convalescent subjects doi: 10.3389/fgene.2021.684152  
  • Eszter Somogyi, Zsolt Csiszovszki, Levente Molnár, Orsolya Lőrincz, József Tóth, Sofie Pattijn, Jana Schockaert, Aurélie Mazy, István Miklós, Katalin Pántya, Péter Páles, Enikő R. Tőke: Peptide vaccine candidate mimics the heterogeneity of natural SARS-CoV-2 immunity in convalescent humans and induces broad T cell responses in mice models doi: https://doi.org/10.1101/2020.10.16.339937  
  • Verstrepen BE, Oostermeijer H, Fagrouch Z, van Heteren M, Niphuis H, Haaksma T, Kondova I, Bogers WM, de Filette M, Sanders N, Stertman L, Magnusson S, Lőrincz O,Lisziewicz J, Barzon L, Palù G, Diamond MS, Chabierski S, Ulbert S, Verschoor EJ: Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus. PLoS One. 2014 Nov 13;9(11):e112568. doi: 10.1371/journal.pone.0112568. PubMed PMID: 25392925.
  • De Filette M, Soehle S, Ulbert S, Richner J, Diamond MS, Sinigaglia A, Barzon L, Roels S, Lisziewicz J, Lőrincz O, Sanders NN: Vaccination of mice using the West Nile virus E- protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal PLoS One, 2014, in press.
  • Garaczi E, Szabó K, Francziszti L, Csiszovszki Z, Lőrincz O, Tőke ER, Molnár L, Bitai T, Jánossy T, Bata-Csörgő Z, Kemény L, Lisziewicz J. DermAll nanomedicine for allergen- specific Nanomedicine. 2013 Nov;9(8):1245-54. doi: 10.1016/j.nano.2013.05.011. Epub 2013 Jun 6. PubMed PMID: 23747740.

Vaccine formulation

  • Lisziewicz J, Tőke ER. Nanomedicine applications towards the cure of HIV. 2013 Jan;9(1):28-38. doi: 10.1016/j.nano.2012.05.012. Epub 2012 May 30. Review. PubMed PMID: 22659241.
  • Lőrincz O, Tőke ER, Somogyi E, Horkay F, Chandran PL, Douglas JF, Szebeni J, Lisziewicz J. Structure and biological activity of pathogen-like synthetic Nanomedicine. 2012 May;8(4):497-506. doi:10.1016/j.nano.2011.07.013. Epub 2011 Aug 10. PubMed PMID: 21839051; PubMedCentral PMCID: PMC3274662.
  • Tőke ER, Lőrincz O, Somogyi E, Lisziewicz J. Rational development of a stable liquid formulation for nanomedicine products. Int J Pharm. 2010 Jun 15;392(1-2):261-7. doi: 10.1016/j.ijpharm.2010.03.048. Epub 2010 Mar 25. PubMed PMID: 20347027.

Vaccine delivery

  • Kolonics A, Csiszovszki Z, Tőke ER, Lőrincz O, Haluszka D, Szipőcs R.: In vivo study of targeted nanomedicine delivery into Langerhans cells by multiphoton laser scanning microscopy. Experimental Dermatology, 2014. 23(8):596-605. PubMed PMID: 24903756.
  • Tőke ER, Lőrincz O, Csiszovszki Zs, Somogyi E, Felföldi G, Molnár L, Szipőcs R, Kolonics A, Malissen B, Lori F, Trocio J, Bakare N, Horkay F, Romani N, Tripp CH, Stoitzner P and Lisziewicz J: Exploitation of Langerhans cells for in vivo DNA vaccine delivery into the lymph nodes. Gene Therapy, 2014. Jun;21(6):566-74. PubMed PMID: 24694539.
  • Somogyi E, Xu J, Gudics A, Tóth J, Kovács AL, Lori F, Lisziewicz J. A plasmid DNA immunogen expressing fifteen protein antigens and complex virus-like particles (VLP+) mimicking naturally occurring HIV. Vaccine. 2011 Jan 17;29(4):744-53. doi: 10.1016/j.vaccine.2010.11.019. Epub 2010 Nov 23. PubMed PMID: 21109034.

Basic research

  • Somogyi E, Lisziewicz J. HIV vaccine to induce cytotoxic T cells recognizing conserved HIV-1/2-epitopes derived from the most frequent HLA types of the human population. 2013 Aug;5(8):825-8. doi: 10.2217/imt.13.79. PubMed PMID: 23902551.
  • Simon L, Toth J, Molnar L, Agoston DV. MRI analysis of mGluR5 and mGluR1 antagonists, MTEP and R214127 in the cerebral forebrain of awake, conscious rats. Neuroscience Letters. 2011 Nov 14;505(2):155-9 PubMed PMID: 22015763.
  • Hellner G, Tőke ER, Nagy V, Szakács GY, Poppe L. Integrated enzymatic production of specific structured lipid and phytosterol ester compositions. Process Biochemistry, 45, 2010, 1245-1250.
  • Csajági CS, Szatzker G, Tőke ER, Ürge L, Darvas F, Poppe L. Enantiomer selective acylation of racemic alcohols by lipases in continous-flow reactors, Tetrahedron: Asymmetry, 19, 2008, 237-246.
  • Szigeti M, Tőke ER, Turóczi MC, Nagy V, Szakács GY, Poppe L. Lipase-catalysed kinetic resolution of 4-aryl- and 4-heteroarylbut-3-en-2-ols, Issue in Honor of Prof Csaba Szántay, Arkivoc, (iii), 2008, 54-65.
  • Tőke ER, Nagy V, Recseg K, Szakács GY, Poppe L. Production and application of novel sterol esterases from Aspergillus strains by solid state fermentation. Journal of American Oil Chemical Society, 84, 2007, 907-915.
  • Nagy V, Tőke ER, Keong  LCH,  Szatzker  G,  Ibrahim  D,  Cheomar I, Szakács GY, Poppe L. Kinetic resolutions with novel, highly enantioselective fungal lipases produced by solid state fermentation. Journal of Molecular Catalysis B: Enzymatic, 39, 2006, 141-148.
  • Tőke ER, Kolonits P, Novák L, Poppe L. Lipase mediated enantiomer and diastereomer separation of 2,2’-[1,2-and 1,3-phenylenebis(oxy)]dicyclohexanols, Tetrahedron: Asymmetry, 17, 2006, 2377-2385.
  • Kmecz I, Simándi B, Poppe L, Juvancz Z, Renner K, Bódai V, Tőke ER, Csajági CS, Sawinsky J. Lipase-catalyzed Enantioselective Acylation of 3- Benzyloxypropane-1,2-diol in Supercritical Carbon Dioxide, Biochemical. Engineering. Journal, 28, 2006, 275-280.
  • Dijkstra A J, Tőke ER, Kolonits P, Recseg K, Kővári K, Poppe L. The Base-Catalysed, Low-Temperature Interesterification Mechanism Revisited, Eur. J. Lipid Sci. Technol., 107, 2005, 912-921.
  • Szatzker G, Pilbák S, Tőke  ER, Bódai  V, Poppe    Enantioselectivity  in Candida antarctica lipase B reaction: transition states calculated by QM/MM methods, 30th FEBS Congress and 9th IUBMB Conference, FEBSJ., 272, 2005, 114, 2-7 july 2005, Budapest, Hungary.
  • Czeglédi A, Ujvári D, Somogyi E, Wehmann E, Werner O, Lomniczi, B. Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications. Virus Res. 120, 2006, 36–48.
  • Jakab IN, Lorincz O, Jancso A, Gajda T, Gyurcsik B. Approaching the minimal metal ion binding peptide for structural and functional metalloenzyme mimicking. Dalton transactions. (Cambridge, England : 2003). 2008(48):6987-95.
  • Semsey S, Pedersen L, Csiszovszki Z, Erdossy J, Steger V, Krishna S. The effect of LacI autoregulation on the performance of the lactose utilization system in Escherichia coli. Nucleic Acid Research. 41(13), 2013, 6381-6390.
  • Csiszovszki Z, Lewis D, Le P, Sneppen K, Semsey S. Specific contacts of the -35 region of the galP1 promoter by RNA polymerase inhibit GalR mediated DNA looping repression. Nucleic Acid Research. 40(20), 2012, 10064-72.
  • Csiszovszki Z, Krishna S, Orosz L, Adhya S, Semsey S. Structure and Function of D-galactose network in Enterobacteria. mBio. 2(4), 2011, e00053-11.
  • Bendsten KM, Erdossy J, Csiszovszki Z, Svenningsen S, Sneppen K, Krishna S, Semsey S. Direct and indirect effects in the regulation of overlapping promoters. Nucleic Acid Research. 39(16), 2011, 6879-85.
  • Semsey S, Benjamin JA, Mitarai N, Krishna S, Csiszovszki Z, Sneppen K, Massé E. Dynamics of the recovery from sRNA-mediated gene silencing. Cell Cycle. 8, 2009, 2863-4.
  • Mitarai N, Benjamin JA, Krishna S, Semsey S, Csiszovszki Z, Massé E, Sneppen K. Dynamic features of gene expression control by small regulatory RNAs. Proc Natl Acad Sci U S A. 106, 2009, 10655-9.
  • Ganyu A, Csiszovszki Z, Ponyi T, Kern A, Buzás Z, Orosz L, Papp PP. Identification of cohesive ends and genes encoding the terminase of phage 16-3. J Bacteriol. 187, 2005, 2526-2531.
  • Blaha B, Semsey S, Ferenczi S, Csiszovszki Z, Papp PP, Orosz L. A proline tRNA(CGG) gene encompassing the attachment site of temperate phage 16-3 is functional and convertible to suppressor tRNA. Mol. Microbiol. 54, 2004, 742-754.
  • Ferenczi S, Ganyu A, Blaha B, Semsey S, Nagy T, Csiszovszki Z, Orosz L, Papp PP. Integrative plasmid vectors for constructing single-copy reporter systems to study gene regulation in Rhizobium meliloti and related species. Plasmid. 52, 2004, 57-62.
  • Csiszovszki Z, Buzás Z, Semsey S, Ponyi T, Papp PP, Orosz L. The immX immunity region of Rhizobium Phage 16-3: two overlapping cistrons of repressor function. J Bacteriol. 185, 2003, 4382-4392.
  • Papp PP, Nagy T, Ferenczi S, Élő P, Csiszovszki Z, Buzás Z, Patthy A, Orosz L. Binding sites of different geometries for the 16-3 phage repressor. Proc Natl Acad Sci U.S.A. 99, 2002, 8790-8795.